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[1]申永存,徐维赟.1S二苯基膦2R二(3，5二甲基苯基)膦二茂铁的合成[J].武汉工程大学学报,2010,(05):22-24.[doi:10.3969/j.issn.16742869.2010.05.006]
　SHEN Yong cun,XU Wei yun.Synthesis of (R)1［(S)2（Diphenylphosphino）ferrocenyl］ethyldi3,5xylylphosphine[J].Journal of Wuhan Institute of Technology,2010,(05):22-24.[doi:10.3969/j.issn.16742869.2010.05.006]
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1S二苯基膦2R二(3，5二甲基苯基)膦二茂铁的合成
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《武汉工程大学学报》[ISSN:1674-2869/CN:42-1779/TQ]

卷:
期数:
2010年05期
页码:
22-24
栏目:
化学与化学工程
出版日期:
2010-05-31

文章信息/Info

Title:
Synthesis of (R)1［(S)2（Diphenylphosphino）
ferrocenyl］ethyldi3,5xylylphosphine
文章编号:
16742869(2010)05002203
作者:
申永存; 徐维赟
武汉理工大学化学工程学院制药工程系，湖北 武汉 430070
Author(s):
SHEN Yongcun; XU Weiyun
Department of Pharmaceutical Engineering，Wuhan University of Technology，Wuhan 430070，China
关键词:
1S二苯基膦2R二(3; 5二甲基苯基)膦二茂铁; 手性二茂铁类双膦配体; 合成
Keywords:
(R)1［(S)2（Diphenylphosphino）ferrocenyl］ethyldi3; 5xylylphosphine;  chiral ferrocenyldiphosphine ligands;  synthesis
分类号:
TQ460.31
DOI:
10.3969/j.issn.16742869.2010.05.006
文献标志码:
A
摘要:
以廉价的二茂铁为原料经付克酰化、还原、酯化、胺解、拆分等反应得RN,N二甲基胺乙基二茂铁，经锂化等多步反应得到高立体选择性的1S二苯基膦2R二(3，5二甲基苯基)膦二茂铁.整个反应过程操作简单，收率达14.6%.产品结构经氢谱、碳谱、磷谱确证.研究结果表明：该路线可行，能够满足工业化大生产的要求.
Abstract:
The cheap ferrocene was used as the starting material to synthesize (R)N,NDimethyl1ferrocenylethylamine by FC acylation, reduction, esterification, amination and resolution. (S)1N,Ndimethyl［2(R)(diphenylphosphino)ferrocenyl］ethylamine was obtained by high enantioselectve reaction of (R)N,NDimethyl1ferrocenylethylamine and Ph2Cl, then the target compound (R)1［(S)2（diphenylphosphino）ferrocenyl］ethyldi3,5xylylphosphine was manufacturated by substitution of Xyl2PH and (S)1N,Ndimethyl［2(R)(diphenylphosphino)ferrocenyl］ethylamine. The total yield was 14.6% and its purity was 97%. The structure was confirmed by 1HNMR, 13CNMR, 31PNMR. The results showed that the route is feasible, the operation is simple, safe, and yield of the product is higher.The synthesis route could meet the demands of large industrial production.

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期：20090622作者简介：申永存（1966），男，湖北武汉人，教授，博士，硕士研究生导师.研究方向：新药的合成与筛选、不对称合成、抗病毒药物的合成及工艺研究.
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