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[1]严少康,刘永红,黎璐平,等.头孢克肟固体分散体的制备及溶出度测定[J].武汉工程大学学报,2011,(11):27-30.
　YAN Shao kang,LIU Yong hong,LI Lu ping,et al.Preparation and dissolution of cefixime solid dispersion[J].Journal of Wuhan Institute of Technology,2011,(11):27-30.
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头孢克肟固体分散体的制备及溶出度测定(/HTML)
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《武汉工程大学学报》[ISSN:1674-2869/CN:42-1779/TQ]

卷:
期数:
2011年11期
页码:
27-30
栏目:
化学与化学工程
出版日期:
2011-11-30

文章信息/Info

Title:
Preparation and dissolution of cefixime solid dispersion
文章编号:
16742869(2011)11002704
作者:
严少康1; 刘永红2; 黎璐平1; 肖芳1; 刘永琼1*
1.武汉工程大学化工与制药学院，绿色化工过程省部共建教育部重点实验室，
湖北省新型反应器与绿色化学工艺重点实验室，湖北 武汉 430074；
2.湖北省襄樊市中心医院，湖北 襄樊 441021
Author(s):
YAN Shaokang1; LIU Yonghong2; LI Luping1; XIAO Fang1; LIU Yongqiong1
1.Key laboratory for Green Chemical Process of Ministry of Education，
Hubei key Laboratory of Novel Chemical reacfor& Green Chemical Technotogy，
School of Chemical Engineering&Pharmacy，Whan Institute of Technotogy，Wuhan 430074,China；
2.Xiangfan Central Hospital，Xiangfan 441021，China
关键词:
头孢克肟; 固体分散体; 制备; 溶出度; 红外光谱
Keywords:
cefixime; solid diapersion; preparation;  dissolution; infrared spectrum
分类号:
TQ460.4
DOI:
-
文献标志码:
AAdoi:10.3969/j.issn.16742869.2011.11.007
摘要:
采用固体分散体技术提高头孢克肟在水中的溶解度，以提高生物利用度.以A为载体，采用溶剂熔融法制备头孢克肟固体分散体.用正交设计方法优选制剂工艺，确定出最优处方为：头孢克肟载体A乙醇=l48 (g/g/g).选用红外光谱法对头孢克肟固体分散体进行物相鉴定，并测定其溶出度.结果表明：头孢克肟载体A(14）固体分散体在水中(20 ℃）的溶出度为95.2％，明显高于原料药(24.8％）及物理混合物(28.6％）；红外光谱法检测出头孢克肟固体分散体在1 780 cm-1附近处的羰基吸收峰的强度大幅度降低.说明采用溶剂熔融法形成了头孢克肟固体分散体.头孢克肟形成稳定的固体分散体后，溶出度显著提高.
Abstract:
The technology of solid dispersion to improve the dissolution of cefixime and its bioavailability was used.Taking A as the carrier,using solventmelting method to prepare the cefixime solid diapersion and using orthogonal design to perfect preparation technology,the best prescription was cefiximecarrierAalcohol=148 (g/g/g).Choosing the technology of infrared spectrum to identify the phase of cefixime solid diapersion and determine its dissolution,the result shows that the dissolution of cefiximecarrierA(14) solid dispersion 95.2％ is obviousiy exceeding the active pharmaceutical ingredient 24.8％ and physics mixture 28.6％.Using solventmelting method can shape solid diapersion better which was explained by the detection of infrared spectrum.The strength of Cefixime and carrier’s crystalloid absorption peak dropped drastically at 1 780 cm-1.The conclusion is that the dissolution can be improved when cefixime formed solid diapersion.

参考文献/References:

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