|本期目录/Table of Contents|

[1]冯菊红,荣霞,孟熙,等.6甲氧基2苯并噁唑酮合成工艺[J].武汉工程大学学报,2011,(12):18-19.
　FENG Ju hong,RONG Xia,MENG Xi,et al.Improvement for synthesis of 6methoxy2(3H)benzoxazolone[J].Journal of Wuhan Institute of Technology,2011,(12):18-19.
点击复制

6甲氧基2苯并噁唑酮合成工艺(/HTML)
分享到：

《武汉工程大学学报》[ISSN:1674-2869/CN:42-1779/TQ]

卷:
期数:
2011年12期
页码:
18-19
栏目:
化学与化学工程
出版日期:
2011-12-30

文章信息/Info

Title:
Improvement for synthesis of 6methoxy2(3H)benzoxazolone
文章编号:
16742869(2011)12001802
作者:
冯菊红; 荣霞; 孟熙; 巨修练*
武汉工程大学化工与制药学院，绿色化工过程教育部重点实验室，湖北 武汉 430074
Author(s):
FENG Juhong; RONG Xia; MENG Xi; JU Xiulian
Key Laboratory for Green Chemical Process of Ministry of Education,
School of Chemical Engineering and Pharmacy,Wuhan Institute of Technology,Wuhan 430074,China
关键词:
6甲氧基2苯并噁唑酮; 肼; 尿素; 合成工艺
Keywords:
6methoxy2(3H)benzoxazolone; hydrazine; urea; synthesis
分类号:
O657.1
DOI:
-
文献标志码:
AAdoi:10.3969/j.issn.16742869.2011.12.004
摘要:
改进了以3甲氧基苯酚为起始原料，通过硝化、还原和环合反应得到6甲氧基2苯并噁唑酮的合成方法.以水合肼作为还原剂，反应时间短且后处理容易；利用氮气保护，以尿素作为甲酰化试剂可以顺利得到产物，即降低了生产成本，又保证了产物的纯度.
Abstract:
Preparation of 6methoxy2(3H)benzoxazolone from 2nitro5methoxyphenol was improved.Hydrazine as the reductive reagent led to a convenient reaction and workup conditions.In present of nitrogen atmosphere,using urea instead of phenyl chloroformate as the formylation reagent reduced the production costs and obtained the pure product.

参考文献/References:

［1］Morrissey J P,Osbourn A E.Fungal resistance to plant antibiotics as a mechanism of pathogenesis［J］.Microbiology Molecular and Biology Review,1999,63：708724.
［2］Poupaert J,Carato P,Colacino E,et al.2(3H)benzoxazolone and bioisosters as “privileged scaffold” in the design of pharmacological probes［J］.Current Medicinal Chemistry,2005,12：877885.
［3］Sam J,Valentine F L.Preparation and properties of 2benzoxazolinones［J］.Journal of Pharmaceutical Sciences,1969,58：10431054.
［4］Wahlroos O,Virtanen A I.Antifungal effect of benzoxazolinone and 6methoxybenzoxazolinone on Fusarium nivale［J］.Acta Chemical Scandinavica,1958,12：124128.
［5］Campos F,Atkinson J,Arnason J T,et al.Toxicity and toxicokinetics of 6methoxybenzoxazolinone (MBOA) in the European corn borer,Ostrinia nubilalis (Huebner)［J］.Journal of Chemical Ecology,1988,14：9891002.
［6］Maleski R J.Improved procedures for the preparation of 24nitro5 methoxyphenol and 6methoxy2(3H)benzoxazolone from 3methoxyphenol［J］.Synthesis Communication,1993,23：343348.
［7］Sicker D.A facile synthesis of 6methoxy2oxo2,3dihydrobenzoxazole［J］.Synthesis,1989,11：875876.
［8］Nachman R J.oHydroxyphenylureas:Intermediates in the urea fusion synthesis of 2benzoxazolinones［J］.Journal of Heterocyclic Chemistry,1983,20：14231425.
［9］Nachman R J.Convenient preparation of 2benzoxazolinones with 1,1carbonyldiimidazole［J］.Journal of Heterocyclic Chemistry,1982,19：15451574.
(

相似文献/References:

备注/Memo

备注/Memo:
-
更新日期/Last Update: