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[1]王凯,等.2,2-二异丙基丙腈的合成[J].武汉工程大学学报,2012,(8):24-25,30.[doi:103969/jissn16742869201208006]
　WANG Kai,LIU Yu hua,WAN Xing,et al.Synthetic improvement of 2, 2Diisopropylpropionitrile[J].Journal of Wuhan Institute of Technology,2012,(8):24-25,30.[doi:103969/jissn16742869201208006]
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2,2-二异丙基丙腈的合成
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《武汉工程大学学报》[ISSN:1674-2869/CN:42-1779/TQ]

卷:
期数:
2012年8期
页码:
24-25,30
栏目:
化学与化学工程
出版日期:
2012-09-10

文章信息/Info

Title:
Synthetic improvement of 2, 2Diisopropylpropionitrile
文章编号:
16742869(2012)08002402
作者:
王凯1;  2; 刘玉华1; 万幸1; 张秀兰1; 张珩1; 万春杰1
1. 武汉工程大学湖北省新型反应器与绿色化学工艺重点实验室，湖北 武汉430074;
2. 武汉工程大学国际学院，湖北 武汉 430074
Author(s):
WANG Kai1; 2;  LIU Yuhua1;  WAN Xing1;  ZHANG Xiulan1;  ZHANG Heng1;  WAN Chunjie1
1. Hubei Key Lab of Novel Reactor & Green Chemical Technology, Wuhan Institute of Technology, Wuhan 430074, China;
2. School of International Education, Wuhan Institute of Technology, Wuhan 430074, China
关键词:
工艺改进; 凉味剂;  异丙基甲磺酸酯
Keywords:
process improvement;  cooling agents;  isopropyl mesylate ester
分类号:
TQ463.2;O623.2
DOI:
103969/jissn16742869201208006
文献标志码:
A
摘要:
针对原有工艺条件的操作条件苛刻和反应原料贵的缺点，设计并实施了一种制备2, 2-二异丙基丙腈的方法.首先，在吡啶的存在下，甲磺酰氯与异丙醇缩合制备异丙基甲磺酸酯.不经分离，直接与丙腈反应，在氨基钠的作用下发生缩合反应，合成得到2, 2-二异丙基丙腈，总收率81.3%，含量98%.结果表明：能有效通过改变起始原料和工艺过程，使得原料易得，操作条件温和，更好地满足工业化生产要求，具有潜在的工业化价值.
Abstract:
To improve the harsh operating conditions and expensive reactants in the original process conditions, a process for preparing 2, 2diisopropylpropionitrile method was designed and implemented. In the presence of pyridine, isopropyl mesylate ester was prepared with methanesulfonyl chloride and isopropyl alcohol, and it was not purified further to synthesize 2, 2diisopropylpropionitrile with propionitrile in the system of amino sodium. At last the 2, 2diisopropylpropionitrile with total yield of 81.3% and purity of 98% was obtained. The results show that the raw material is gained easily and the mild operating conditions are obtained through changing the starting raw materials and technological process，which meets industrial production requirements

参考文献/References:

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［7］王凯, 黄婷, 张天畅, 等. 2,5二氨基4,6二羟基嘧啶盐酸盐的合成\[J\]. 武汉工程大学学报, 2011, 33 (5): 2224.

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备注/Memo

备注/Memo:
稿日期：20120515基金项目：国家自然科学基金（20902071）作者简介：王凯(1976)，男，湖北武汉人，副教授，博士.研究方向：医药产品研发、中试放大、技术革新和药品申报.
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