[1] 郑洪艳, 徐为人. 小檗碱药理作用研究进展[J]. 中草药, 2004, 35(6):708-711. [2] 李波, 朱维良, 陈凯先. 小檗碱及其衍生物的研究进展[J]. 药学学报, 2008, 43(8):773-787. [3] AMIN A H, SUBBAIAH T V, ABBASI K M. Berberine sulfate: antimicrobial activity, bioassay, and mode of action[J]. Canadian Journal of Microbiology, 1969, 15(9):1067-1076. [4] 张灿, 黄文龙. 原小檗碱季铵类化合物的合成及抗心律失常活性研究[J]. 中国药科大学学报, 2003, 34(1):7-12. [5] LIN C C, NG L T, HSU F F, et al. Cytotoxic effects of Coptis chinensis and Epimedium sagittatum extracts and their major constituents (berberine, coptisine and icariin) on hepatoma and leukaemia cell growth[J]. Clinical & Experimental Pharmacology & Physiology, 2004, 31(1/2):65-69. [6] YIN J, HU R, CHEN M, et al. Effects of berberine on glucose metabolism in vitro. [J]. Metabolism: Clinical and Experimental, 2002, 51(11):1439-1443. [7] KONG W, WEI J, ABIDI P, et al. Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins [J]. Nature Medicine, 2004, 10(12):1344-1451. [8] 胡文祥,徐楠楠,王卓,等. 一种降糖及降脂药物组合物及其制备方法:中国,200710179390.3[P]. 2007-12-12. [9] 张磊, 王京, 聂晶, 等. 四氢小檗碱衍生物的合成与表征[J]. 广东化工, 2014, 41(15):36-37. [10] 王冬梅, 魏金钊, 范宝妍,等. 四氢黄连碱型季铵化合物的合成及生物活性研究[J]. 药学学报, 2012(12):1640-1645. [11] 杨勇. 8-烷基小檗碱同系物的合成与药理活性[D]. 重庆:西南大学, 2008. [12] 胡宇莉. 8-十六烷基小檗碱的合成和药代动力学研究[D]. 重庆:西南大学, 2015. [13] IWASSA K, KAMIGAUCHI M. 13-hydroxylation of tetrahydroberberine in cell suspension cultures of some Corydalis, species[J]. Phytochemistry, 1996, 41(6):1511-1515. [14] 韩谢, 邵开元, 胡文祥. 微波辐射合成9-氧-2-溴乙基小檗碱工艺研究[J]. 微波化学, 2017,1(1): 8-14. [15] CHEN Z, YE X, YI J, et al. Synthesis of 9-O-glycosyl-berberine derivatives and bioavailability evaluation[J]. Medicinal Chemistry Research, 2012, 21(8):1641-1646. [16] KIM S H, LEE S J, LEE J H, et al. Antimicrobial activity of 9-O-acyl- and 9-O-alkylberberrubine derivatives. [J]. Planta Medica, 2002, 68(3):277-281. [17] ZHANG S, WANG X, YIN W, et al. Synthesis and hypoglycemic activity of 9-O-(lipophilic group substituted) berberine derivatives[J]. Bioorganic & Medicinal Chemistry Letters, 2016, 26(19):4799-4803. [18] MISTRY B, KEUM Y S, KIM D H. Synthesis and biological evaluation of berberine derivatives bearing 4-aryl-1-piperazine moieties[J]. Journal of Chemical Research, 2015, 39(8):470-474. [19] SHI A, HUANG L, LU C, et al. Synthesis, biological evaluation and molecular modeling of novel triazole-containing berberine derivatives as acetylcholinesterase and β-amyloid aggregation inhibitors[J]. Bioorganic & Medicinal Chemistry, 2011, 19(7):2298-2305. [20] HUANG M Y, LIN J, HUANG Z J, et al. Design, synthesis and anti-inflammatory effects of novel 9-O-substituted-berberine derivatives[J]. Medlicinal Chemistry Communicaiton, 2016, 7(4):730-731. [21] HUANG L, LUO Z, HE F, et al. Berberine derivatives, with substituted amino groups linked at the 9-position, as inhibitors of acetylcholinesterase/butyrylcholinesterase[J]. Bioorganic & Medicinal Chemistry Letters, 2010, 20(22):6649-6652. [22] FRERICHS G. Beitr?ge zur kenntnis des berberins. ueber berberrubin[J]. Archiv Der Pharmazie, 2010, 251(5):321-339. [23] ZHOU X, CHEN M, ZHENG Z, et al. Synthesis and evaluation of novel 12-aryl berberine analogues with hypoxia-inducible factor-1 inhibitory activity[J]. RSC Advances, 2017, 43(7):26921-26929. [24] 丁阳平, 叶小利, 周洁, 等. 小檗碱衍生物合成及生理活性研究进展[J]. 有机化学, 2012, 32(4):677-685. [25] PARK K D, CHO S J, MOON J S, et al. Synthesis and antifungal activity of a novel series of 13-(4-isopropylbenzyl)berberine derivatives[J]. Bioorganic & Medicinal Chemistry Letters, 2010, 20(22):6551-6554. [26] DING Y, YE X, ZHU J, et al. Structural modification of berberine alkaloid and their hypoglycemic activity[J]. Journal of Functional Foods, 2014, 7(1):229-237. [27] BUROV O N,KURBATOV S V,KLETSKII M E, et al. Synthesis and structure of dihydroberberine nitroaryl derivatives-potential ligands for G-quadruplexes[J]. Chemistry of Heterocyclic Compounds, 2017,53(3):335-340. [28] 赵午莉, 李阳彪, 李迎红,等. 13-取代小檗碱衍生物的合成及其抗肿瘤活性研究[J]. 中国医药导报, 2013, 10(18):17-20.