[1] ZUCKERMAN J A. IARC Monographs on the evaluation of carcinogenic risks to humans[J]. Journal of Clinical Pathology,1995,48(7):691-a. [2] 童志前,万有,罗文鸿,等. 内源性甲醛及其相关人类重大疾病[J].自然科学进展,2008,18(11):1201-1210. [3] CANUTO V M,LEVINE J S,AUGUSTSSON T R,et al. The young sun and the atmosphere and photochemistry of the early earth[J]. Nature,1983,305(5932):281-286. [4] PINTO J P, GLADSTONE G R, YUNG Y L. Photochemical production of formaldehyde in earth’s primitive atmosphere[J]. Science,1980,210(4466):183-185. [5] KALAPOS M P. A possible evolutionary role of formaldehyde[J]. Experimental & Molecular Medicine, 1999,31(1):1-4. [6] TRéZL L,CSIBA A,JUHáSZ S,et al. Endogenous formaldehyde level of foods and its biological significance[J]. European Food Research and Technology, 1997, 205(4):300-304. [7] YU P H, ZUO D M. Formaldehyde produced endogenously via deamination of methylamine. A potential risk factor for initiation of endothelial injury[J]. Atherosclerosis, 1996, 120(1/2):189-197. [8] TENG S, BEARD K, POURAHMAD J, et al. The formaldehyde metabolic detoxification enzyme systems and molecular cytotoxic mechanism in isolated rat hepatocytes[J]. Chemico-Biological Interactions,2001, 130-132(1/2/3):285-296. [9] TULPULE K, HOHNHOLT M C, DRINGEN R. Formaldehyde metabolism and formaldehyde induced stimulation of lactate production and glutathione export in cultured neurons[J]. Journal of Neurochemistry, 2013, 125(2): 260-272. [10] KALáSZ H. Biological role of formaldehyde, and cycles related to methylation, demethylation, and formaldehyde production[J]. Mini Reviews in Medicinal Chemistry, 2003, 3(3):175-192. [11] 郑斌,陈伟斌,徐晓林,等. 液相色谱法测定水产品中游离甲醛含量的研究[J]. 浙江海洋学院学报(自然科学版),2006,25(4):355-358. [12] KILBURN K H,WARSHAW R,THORNTON J C. Formaldehyde impairs memory, equilibrium, and dexterity in histology technicians: effects which persist for days after exposure[J]. Archives of Environmental Health:an International Journal,1987,42(2): 117-120. [13] PARKER B S,CUTTS S M,CULLINANE C,et al. Formaldehyde activation of mitoxantrone yields CpG and CpA specific DNA adducts[J]. Nucleic Acids Research, 2000, 28(4): 982-990. [14] LIN Z, LUO W, LI H, et al. The effect of endogenous formaldehyde on the rat aorta endothelial cells[J]. Toxicology Letters, 2005, 159(2): 134-143. [15] PETER H Y, CAUGLIN C, WEMPE K L, et al. A novel sensitive high-performance liquid chromatography/electrochemical procedure for measuring formaldehyde produced from oxidative deamination of methylamine and in biological samples[J]. Analytical Biochemistry, 2003, 318(2): 285- 290. [16] LYLES G A. Mammalian plasma and tissue-bound semicarbazide-sensitive amine oxidases: biochemical, pharmacological and toxicological aspects[J]. The International Journal of Biochemistry & Cell Biology, 1996, 28(3): 259-274. [17] ANDRéS N, LIZCANO J M, RODRíGUEZ M J, et al. Tissue activity and cellular localization of human semicarbazide-sensitive amine oxidase[J]. Journal of Histochemistry & Cytochemistry,2001,49(2): 209-217. [18] RAMONET D, RODRIGUEZ M, SAURA J, et al. Localization of monoamine oxidase A and B and semicarbazide-sensitive amine oxidase in human peripheral tissues[J]. Inflammopharmacology, 2003, 11(2): 111-117. [19] BIRD A. The essentials of DNA methylation[J]. Cell, 1992, 70(1):5-8. [20] REIK W, DEAN W, WALTER J. Epigenetic reprogramming in mammalian development[J]. Science, 2001, 293(5532): 1089-1093. [21] 王丽, 朱燕, 丁书茂,等. 甲醛与DNA甲基化和去甲基化[J]. 公共卫生与预防医学, 2004, 15(6):28-29. [22] 苏涛, 宋丹, 李婷,等. 核酸(脱)甲基化与内源甲醛及认知损伤[J]. 生物化学与生物物理进展, 2015, 42(3):211-219. [23] 李婷, 苏涛, 赫英舸,等. 甲醛、组蛋白(脱)甲基化与学习记忆[J]. 神经药理学报, 2014, 4(6):21-27.[24] LOPRIENO N. International agency for research on cancer (IARC) monographs on the evaluation of carcinogenic risk of chemicals to man Relevance of data on mutagenicity[J]. Mutation Research/Environmental Mutagenesis and Related Subjects, 1975, 31(3):201. [25] CRIDER K S,YANG T P, BERRY R J, et al. Folate and DNA methylation: a review of molecular mechanisms and the evidence for folate’s role[J]. Advances in Nutrition: an International Review Journal, 2012, 3(1): 21-38. [26] YAN F,FUJIMORI D G. RNA methylation by radical SAM enzymes RlmN and Cfr proceeds via methylene transfer and hydride shift[J]. Proceedings of the National Academy of Sciences,2011,108(10): 3930-3934. [27] WU H, ZHANG Y. Mechanisms and functions of Tet protein-mediated 5-methylcytosine oxidation[J]. Genes & Development, 2011, 25(23): 2436-2452. [28] SANCHEZ-PULIDO L,ANDRADE-NAVARRO M A. The FTO (fat mass and obesity associated) gene codes for a novel member of the non-heme dioxygenase superfamily[J]. BMC Biochemistry, 2007, 8(1):1-6. [29] ZHENG G, DAHL J A, NIU Y, et al. ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility[J]. Molecular Cell, 2013, 49(1): 18-29. [30] QIN Z,ZAIDI A,GAO J,et al. Decrease in Ca-ATPase activity in aged synaptosomal membranes is not associated with changes in fatty acyl chain dynamics[J]. Mechanisms of Ageing and Development, 1998, 105(3): 291-300. [31] GüLE? M, SONGUR A, SAHIN S, et al. Antioxidant enzyme activities and lipid peroxidation products in heart tissue of subacute and subchronic formaldehyde-exposed rats: a preliminary study[J]. Toxicology and Industrial Health, 2006, 22(3):117-124. [32] PETUSHOK N E,PETUSHOK B G,EL’CHANINOVA M A, et al. Functional activity of blood and liver cells under formaldehyde intoxication via inhalation[J]. Biomeditsinskaia Khimiia, 2004, 51(1):76-80. [33] DENK H, MOLDEUS P W, SCHULZ R A, et al. Hepatic organelle interaction. IV. Mechanism of succinate enhancement of formaldehyde accumulation from endoplasmic reticulum N-dealkylations[J]. The Journal of Cell Biology, 1976, 69(3): 589-598. [34] LIRDPRAPAMONGKOL K, SAKURAI H, KAWASAKI N, et al. Vanillin suppresses in vitro invasion and in vivo metastasis of mouse breast cancer cells[J]. European Journal of Pharmaceutical Sciences,2005,25(1): 57-65. [35] TENG S, BEARD K, POURAHMAD J, et al. The formaldehyde metabolic detoxification enzyme systems and molecular cytotoxic mechanism in isolated rat hepatocytes[J]. Chemico-Biological Interactions, 2001, 130: 285-296. [36] JELSKI W, SANI T A, SZMITKOWSKI M. Class III alcohol dehydrogenase and its role in the human body[J]. Postepy Higieny I Medycyny Doswiadczalnej, 2006, 60:406. [37] 童志前, 韩婵帅, 苗君叶,等. 内源性甲醛异常蓄积与记忆衰退[J]. 生物化学与生物物理进展, 2011, 38(6):575-579. [38] MARTíNEZ S E,VAGLENOVA J, SABRIà J, et al. Distribution of alcohol dehydrogenase mRNA in the rat central nervous system[J]. The FEBS Journal, 2001, 268(19): 5045-5056. [39] HO K K, ALLALI-HASSANI A, HURLEY T D, et al. Differential effects of Mg2+ ions on the individual kinetic steps of human cytosolic and mitochondrial aldehyde dehydrogenases[J]. Biochemistry, 2005, 44(22): 8022-8029. [40] OYAMA T, ISSE T, KAGAWA N, et al. Tissue-distribution of aldehyde dehydrogenase 2 and effects of the ALDH2 gene-disruption on the expression of enzymes involved in alcohol metabolism[J]. Front Biosci, 2005, 10(1): 951-960. [41] ESTONIUS M, SVENSSON S, H??G J O. Alcohol dehydrogenase in human tissues: localisation of transcripts coding for five classes of the enzyme[J]. Febs Letters, 1996, 397(2/3): 338-342. [42] UOTILA L, KOIVUSALO M. Expression of formaldehyde dehydrogenase and S-formylglutathione hydrolase activities in different rat tissues[J]. Advances in Experimental Medicine & Biology, 1997, 414:365-371. [43] MORI O, HASEBA T, KAMEYAMA K, et al. Histological distribution of class III alcohol dehydrogenase in human brain[J]. Brain Research, 2000, 852(1): 186-190. [44] NIE C L,WEI Y,CHEN X,et al. Formaldehyde at low concentration induces protein Tau into globular amyloid-like aggregates, In Vitro, and, In Vivo[J]. Plos One, 2006, 2(7):e629. [45] NIE C L,ZHANG W,ZHANG D,et al. Changes in conformation of human neuronal tau during denaturation in formaldehyde solution[J]. Protein & Peptide Letters, 2005, 12(1):75-78. [46] GULEC M, SONGUR A, SAHIN S, et al. Antioxidant enzyme activities and lipid peroxidation products in heart tissue of subacute and sub-chronic formaldehyde exposed rats; a preliminary study[J]. Toxicol and Health, 2006, 22(3):117-124. [47] YU P H, ZUO D M. Oxidative deamination of methylamine by semicarbazidesensitive amine oxidase leads to cytotoxic damage in endothelial cells possible consequences for dia-betes[J]. Diabetes,1993, 42(4):594-603. [48] TYIHáK E, BOCSI J, TIMáR F, et al. Formaldehyde promotes and inhibits the proliferation of cultured tumour and endothelial cells[J]. Cell Proliferation, 2001,34(3):135-141. [49] YU P H, DENG Y L. Endogenous formaldehyde as a potential factor of vulnerability of atherosclerosis: involvement of semicarbazide-sensitive amine oxidase-mediated methylamine turnover[J]. Atherosclerosis, 1998, 140(2): 357-363. [50] SOFFRITTI M, BELPOGGI F, LAMBERTIN L, et al. Results of long-term experimental studies on the carcinogenicity of formaldehyde and acetaldehyde in rats[J]. Annals of the New York Academy of Sciences, 2002, 982(1): 87-105. [51] HANSON A D, ROJE S. One-carbon metabolism in higher plants.[J]. Annual Review of Plant Physiology & Plant Molecular Biology,2001,52(52):119-137. [52] ACHKOR H, DíAZ M, FERNáNDEZ M R, et al. Enhanced formaldehyde detoxification by overexpression of glutathione-dependent formaldehyde dehydrogenase from Arabidopsis[J]. Plant Physiology,2003,132(4): 2248-2255. [53] FUKUSAKI E I, IKEDA T, SHIRAISHI T, et al. Formate dehydrogenase gene of arabidopsis thaliana is induced by formaldehyde and not by formic acid[J]. Journal of Bioscience and Bioengineering, 2000, 90(6): 691-693. [54] CROWTHER G J, KOSáLY G, LIDSTROM M E. Formate as the main branch point for methylotrophic metabolism in methylobacterium extorquens AM1[J]. Journal of Bacteriology, 2008, 190(14): 5057-5062. [55] YURIMOTO H, KATO N, SAKAI Y. Assimilation, dissimilation, and detoxification of formaldehyde, a central metabolic intermediate of methylotrophic metabolism[J]. The Chemical Record, 2005, 5(6): 367-375. [56] ARPS P J, FULTON G F, MINNICH E C, et al. Genetics of serine pathway enzymes in methylobacterium extorquens AM1:phosphoenolpyruvate carboxylase and malyl coenzyme A lyase.[J]. Journal of Bacteriology,1993,175(12):3776-3783. [57] KATO N, YURIMOTO H, THAUER R K. The physiological role of the ribulose monophosphate pathway in bacteria and archaea[J]. Bioscience, Biotechnology and Biochemistry, 2006, 70(1): 10-21. [58] FERENCI T, STR?M T, QUAYLE J R. Purification and properties of 3-hexulose phosphate synthase and phospho-3-hexuloisomerase from methylococcus capsulatus[J]. Biochemical Journal,1974,144(3): 477-486. [59] 金晶,吴婉欣,陈雯雯,等. 微生物甲醛代谢途径的研究进展[J]. 吉林农业,2011(4): 70-72. [60] VORHOLT J A, MARX C J, LIDSTROM M E, et al. Novel formaldehyde-activating enzyme in methylobacterium extorquens AM1 required for growth on methanol[J]. Journal of Bacteriology, 2000, 182(23):6645-6650. [61] WELANDER P V, METCALF W W. Mutagenesis of the C1 oxidation pathway in methanosarcina barkeri: new insights into the Mtr/Mer bypass pathway[J]. Journal of Bacteriology, 2008, 190(6): 1928-1936.