|本期目录/Table of Contents|

[1]熊金辉,柏正武*.壳聚糖氨基选择性功能化中的空间位阻效应[J].武汉工程大学学报,2019,(04):322-326,333.[doi:10. 3969/j. issn. 1674?2869. 2019. 04. 004]
　XIONG Jinhui,BAI Zhengwu*.Influence of Steric Hindrance on Amino-Selective Functionalization of Chitosan[J].Journal of Wuhan Institute of Technology,2019,(04):322-326,333.[doi:10. 3969/j. issn. 1674?2869. 2019. 04. 004]
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壳聚糖氨基选择性功能化中的空间位阻效应(/HTML)
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《武汉工程大学学报》[ISSN:1674-2869/CN:42-1779/TQ]

卷:
期数:
2019年04期
页码:
322-326,333
栏目:
化学与化学工程
出版日期:
2019-09-27

文章信息/Info

Title:
Influence of Steric Hindrance on Amino-Selective Functionalization of Chitosan
文章编号:
20190404
作者:
熊金辉; 柏正武*
武汉工程大学化学与环境工程学院，湖北 武汉 430205
Author(s):
XIONG Jinhui;  BAI Zhengwu*
School of Chemistry and Environmental Engineering， Wuhan Institute of Technology， Wuhan 430205， China
关键词:
壳聚糖; 空间位阻; 选择性功能化; 取代度
Keywords:
chitosan; steric hindrance; selective functionalization; degree of substitution
分类号:
O633
DOI:
10. 3969/j. issn. 1674?2869. 2019. 04. 004
文献标志码:
A
摘要:
为探索空间位阻效应对壳聚糖的N-酰基化、脲基化和氨基甲酸酯化这3种反应的影响，用不同空间位阻的修饰剂对壳聚糖上的氨基进行衍生化，以1H NMR确定其取代度。结果表明：当修饰试剂的空间位阻不大时，产物的取代度接近100%；而当空间位阻较大时，用离子液体或者LiCl/DMAc为溶剂进行第2次修饰能提高产物的取代度。
Abstract:
To explore influences of steric hindrance on chitosan acylation， ureidolation and carbamylation， the amino group in chitosan was selectively modified by agents with different steric hindrance， and the degree of substitution （DS） was determined by 1H nuclear magnetic resonance spectroscopy. The results demonstrate that the DS can approach 100% with low steric hindrance. When the steric hindrance of the agent is high， the DS can increase by the second modification with an ionic liquid or LiCl/DMAc as the solvent.

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期：2019-01-22 基金项目：国家自然科学基金（51373127）作者简介：熊金辉，硕士研究生。E-mail：[email protected]*通讯作者：柏正武，博士，教授。E-mail：[email protected]引文格式：熊金辉，柏正武. 壳聚糖氨基选择性功能化中的空间位阻效应［J］. 武汉工程大学学报，2019，41（4）：322-326，333.
更新日期/Last Update: 2019-08-05