|本期目录/Table of Contents|

[1]郭远哲,毛思颖,罗晓刚*.原位制备ZIF-8/纤维素微球及其控制释放5-氟尿嘧啶的研究[J].武汉工程大学学报,2024,46(02):137-147.[doi:10.19843/j.cnki.CN42-1779/TQ.202303020]
　GUO Yuanzhe,MAO Siying,LUO Xiaogang*.ZIF-8/cellulose microspheres prepared in situ tocontrol release of 5-fluorouracil[J].Journal of Wuhan Institute of Technology,2024,46(02):137-147.[doi:10.19843/j.cnki.CN42-1779/TQ.202303020]
点击复制

原位制备ZIF-8/纤维素微球
及其控制释放5-氟尿嘧啶的研究
(/HTML)
分享到：

《武汉工程大学学报》[ISSN:1674-2869/CN:42-1779/TQ]

卷:
46
期数:
2024年02期
页码:
137-147
栏目:
材料科学与工程
出版日期:
2024-04-28

文章信息/Info

Title:
ZIF-8/cellulose microspheres prepared in situ to
control release of 5-fluorouracil
文章编号:
1674 - 2869（2024）02 - 0137- 11
作者:
郭远哲1; 毛思颖1; 罗晓刚*1; 2
1. 武汉工程大学化工与制药学院，绿色化工过程教育部重点实验室（武汉工程大学），湖北 武汉 430205；
2. 湖北三峡实验室，湖北 宜昌 443007
Author(s):
GUO Yuanzhe1; MAO Siying1; LUO Xiaogang*1; 2
1. School of Chemical Engineering and Pharmacy，Wuhan Institute of Technology；Key Laboratory of Green Chemical Process of Ministry of Education（Wuhan Institute of Technology），Wuhan 430205，China；
2. Hubei Three Gorges Laboratory，Yichang 443007，China
关键词:
纤维素微球; ZIF-8; 5-氟尿嘧啶; 控制释放
Keywords:
cellulose microspheres;  ZIF-8;  5-fluorouracil;  controlled release
分类号:
X703
DOI:
10.19843/j.cnki.CN42-1779/TQ.202303020
文献标志码:
A
摘要:
在纤维素微球（CM）上设计了沸石型咪唑骨架材料8/纤维素复合微球（ZIF-8@CM）作为5-氟尿嘧啶（5-FU）的载体并对5-FU进行控制释放。以CM、硝酸锌和2-甲基咪唑为原料，采用原位法制备了ZIF-8@CM。通过氢键、静电相互作用和π-π堆积作用将5-FU加载到ZIF-8@CM上。利用扫描电子显微术、能量色散X射线分析法、傅里叶变换红外光谱法、X射线衍射、X射线光电子能谱法和热重分析对样品进行表征，结果表明成功制备了ZIF-8@CM，并在ZIF-8@CM上成功加载了5-FU。ZIF-8@CM对5-FU的负载量可达74.10 mg·g-1，远高于CM（2.84 mg·g-1）。此外，ZIF-8@CM-5-FU可在pH=5.0的磷酸缓冲溶液（PBS）环境下持续释放5-FU 600 min，释放量达到63.4%，但在pH=7.4的PBS环境下仅释放37.6%。5-FU的释放遵循一级动力学和Fickian扩散机制。在细胞实验中已证实ZIF-8@CM具有良好的生物相容性和极低的细胞毒性，是5-FU安全释放的合适载体。本研究为设计一种5-FU的新型载体提供了思路。

Abstract:
Zeolitic imidazole framework 8/cellulose composite microsphere（ZIF-8@CM） was designed on the cellulose microsphere（CM） as the carrier of 5-fluorouracil（5-FU） to control the release of 5-FU. ZIF-8@CM was prepared by an in-situ method from CM，zinc nitrate and 2-methylimidazole. 5-FU was loaded on ZIF-8@CM by hydrogen bonding， electrostatic interaction and π-π stacking. The samples were characterized by scanning electron microscopy， energy-dispersion X-ray analysis， Fourier transform infrared spectroscopy， X-ray diffraction， X-ray photoelectron spectroscopy and thermogravimetric analysis. The results show that ZIF-8@CM is successfully prepared and 5-FU is loaded on ZIF-8@CM. The loading capacity of 5-FU can reach 74.10 mg·g-1，much higher than that of CM （2.84 mg·g-1）. In addition，ZIF-8@CM-5-FU can release 63.4% of 5-FU over 600 min in phosphoric acid buffer solution （PBS） at pH=5.0，but only 37.6% in PBS at pH=7.4. The release of 5-FU follows first-order kinetics and Fickian diffusion mechanism. Cell experiments prove that ZIF-8@CM have good biocompatibility and very low cytotoxicity，and ZIF-8@CM-5-FU is a suitable vector for safe release of 5-FU. This study provides an idea for designing a new type of 5-FU carrier.

参考文献/References:

［1］ LONGLEY D B， HARKIN D P， JOHNSTON P G. 5-fluorouracil：mechanisms of action and clinical strategies ［J］. Nature Reviews Cancer，2003，3（5）：330-338.

［2］ SUN X X，LIU C，OMER A M，et al. pH-sensitive ZnO/carboxymethyl cellulose/chitosan bio-nanocomposite beads for colon-specific release of 5-fluorouracil ［J］. International Journal of Biological Macromolecules，2019，128：468-479.
［3］ ENTEZAR-ALMAHDI E， MOHAMMADI-SAMANI S，TAYEBI L，et al. Recent advances in designing 5-fluorouracil delivery systems：a stepping stone in the safe treatment of colorectal cancer ［J］. International Journal of Nanomedicine，2020，15：5445-5458.
［4］ LIU G， FRANSSEN E， FITCH M I， et al. Patient preferences for oral versus intravenous palliative chemotherapy ［J］. Journal of Clinical Oncology，1997，15（1）：110-115.
［5］ JIVRAJ M， MARTINI L G， THOMSON C M. An overview of the different excipients useful for the direct compression of tablets ［J］. Pharmaceutical Science & Technology Today，2000，3（2）：58-63.
［6］ SHEIKHI A， HAYASHI J， EICHENBAUM J， et al. Recent advances in nanoengineering cellulose for cargo delivery ［J］. Journal of Control Release，2019，294：53-76.
［7］ RAMESH BABU V，SAIRAM M，HOSAMANI K M，et al. Preparation of sodium alginate-methylcellulose blend microspheres for controlled release of nifedipine ［J］. Carbohydrate Polymers，2007，69（2）：241-250.
［8］ LUO X G， LIU L M， WANG L R， et al. Facile synthesis and low concentration tylosin adsorption performance of chitosan/cellulose nanocomposite microspheres ［J］. Carbohydrate Polymers，2019，206：633-640.
［9］ LUO X G， LIU S L， ZHOU J P，et al. In situ synthesis of Fe3O4/cellulose microspheres with magnetic-induced protein delivery ［J］. Journal of Materials Chemistry，2009，19（21）：3538-3545.
［10］ KAMALY N，YAMEEN B，WU J，et al. Degradable controlled-release polymers and polymeric nanoparticles：mechanisms of controlling drug release ［J］. Chemical Reviews，2016，116（4）：2602-2663.
［11］ WU S M，GONG Y Q，LIU S L，et al. Functionalized phosphorylated cellulose microspheres：design，characterization and ciprofloxacin loading and releasing properties ［J］. Carbohydrate Polymers，2021，254：117421.
［12］ LEE H，CHI W S，LEE M J，et al. Network-nanostructured ZIF-8 to enable percolation for enhanced gas transport ［J］. Advanced Functional Materials，2022，32（47）：2207775.
［13］ DORNELES de MELLO M，AHMAD M，LEE D T，et al. In situ tracking of nonthermal plasma etching of ZIF-8 films ［J］. ACS Applied Materials & Interfaces，2022，14（16）：19023-19030.
［14］ WANG Q X， LEI Y T， CUI Y Y， et al. Thermal stability and kinetics of single I2@ZIF-8 particles ［J］. ACS Applied Materials & Interfaces，2022，14（19）：22643-22649.
［15］ LIAN H Q，BAO B，CHEN J F，at al. Controllable synthesis of ZIF-8 interlocked membranes for propylene/propane separation ［J］. Separation and Purification Technology，2022，300：121811.
［16］ REN L P， YU Y， YANG Y，et al. Efficient removal of formaldehyde with ZIF-8 growth on TIO2-coated activated carbon fiber felts prepared via atomic layer deposition ［J］. Journal of Materials Science，2020，55（8）：3167-3180.
［17］ WANG Y，YAN J H，WEN N C，et al. Metal-organic frameworks for stimuli-responsive drug delivery ［J］. Biomaterials，2020，230：119619.
［18］ SIMAGINA A A，POLYNSKI M V，VINOGRADOV A V，et al. Towards rational design of metal-organic framework-based drug delivery systems ［J］. Russian Chemical Reviews，2018，87（9）：831-858.
［19］ CAI J，LIU Y T，ZHANG L N. Dilute solution properties of cellulose in LiOH/urea aqueous system ［J］. Journal of Polymer Science： Part B：Polymer Physics，2006，44（21）：3093-3101.
［20］ LUO X G，YUAN J， LIU Y G， et al. Improved solid-phase synthesis of phosphorylated cellulose microsphere adsorbents for?highly effective Pb2+ removal from water：batch and fixed-bed column performance and adsorption mechanism ［J］. ACS Sustainable Chemistry & Engineering，2017，5（6）：5108-5117.
［21］ EBRAHIMI R， SALAVATY M. Controlled drug delivery of ciprofloxacin from ultrasonic hydrogel ［J］. e-Polymers，2018，18（2）：187-195.
［22］ GHOSH S K， DAS A， BASU A， et al. Semi-interpenetrating hydrogels from carboxymethyl guar gum and gelatin for ciprofloxacin sustained release ［J］. International Journal of Biological Macromolecules，2018，120：1823-1833.
［23］ SHARKAWY A，FERNANDES I P，BARREIRO M F，et al. Aroma-loaded microcapsules with antibacterial activity for eco-friendly textile application：synthesis，characterization，release，and green grafting［J］. Industrial & Engineering Chemistry Research，2017，56（19）：5516-5526.
［24］ SILVA M， MARTINS I M， BARREIRO M F， et al. Functionalized textiles with PUU/limonene microcapsules：effect of finishing methods on fragrance release ［J］. The Journal of the Textile Institute，2017，108（3）：361-367.
［25］ LI J， XIN M X， HUO Y H， et al. Synthesis of β-cyclodextrin-PEG-G molecules to delay tumor growth and application of β-cyclodextrin-PEG-G aggregates as drug carrier［J］. Carbohydrate Polymers，2020，229：115478.
［26］ ZHANG H， LUO X G， TANG H， et al. A novel candidate for wound dressing：transparent porous maghemite/cellulose nanocomposite membranes with controlled release of doxorubicin from a simple approach ［J］. Materials Science and Engineering： C，2017，79：84-92.
［27］ JIAN M P， LIU B， ZHANG G S， et al. Adsorptive removal of arsenic from aqueous solution by zeolitic imidazolate framework-8 （ZIF-8） nanoparticles ［J］. Colloids and Surfaces A：Physicochemical and Engineering Aspects，2015，465：67-76.
［28］ GROSS A F，SHERMAN E，VAJO J J. Aqueous room temperature synthesis of cobalt and zinc sodalite zeolitic imidizolate frameworks ［J］. Dalton Transactions，2012，41（18）：5458-5460.
［29］ JIA M M， ZHANG X F， FENG Y， et al. In-situ growing ZIF-8 on cellulose nanofibers to form gas separation membrane for CO2 separation ［J］. Journal of Membrane Science，2020，595：117579.
［30］ LIU B，JIAN M P，LIU R P，et al. Highly efficient removal of arsenic（Ш） from aqueous solution by zeolitic imidazolate frameworks with different morphology ［J］. Colloids and Surfaces A：Physicochemical and Engineering Aspects，2015，481：358-366.
［31］ NABIPOUR H，SADR M H，BARDAJEE G R. Synthesis and characterization of nanoscale zeolitic imidazolate frameworks with ciprofloxacin and their applications as antimicrobial agents ［J］. New Journal of Chemistry，2017，41（15）：7364-7370.
［32］ JAVANBAKHT S，HEMMATI A，NAMAZI H，et al. Carboxymethylcellulose-coated 5-fluorouracil@MOF-5 nano-hybrid as a bio-nanocomposite carrier for the anticancer oral delivery ［J］. International Journal of Biological Macromolecules，2020，155：876-882.
［33］ YU L，CHEN H X，YUE J，et al. Metal-organic framework enhances aggregation-induced fluorescence of chlortetracycline and the application for detection ［J］. Analytical Chemistry，2019，91（9）：5913-5921.
［34］ GONG X Y，WANG Y X，CHEN L Y. Enhanced emulsifying properties of wood-based cellulose nanocrystals as Pickering emulsion stabilizer ［J］. Carbohydrate Polymers，2017，169：295-303.
［35］ ZHAI X C，LIN D H，LI W W，et al. Improved characterization of nanofibers from bacterial cellulose and its potential application in fresh-cut apples ［J］. International Journal of Biological Macromolecules，2020，149：178-186.
［36］ COUDERT F X.Molecular mechanism of swing effect in zeolitic imidazolate framework ZIF-8：continuous deformation upon adsorption ［J］. ChemPhysChem，2017，18（19）：2732-2738.
［37］ 沈浩，黄茜，冯锐捷，等. Zr掺杂介孔硅对亚甲基蓝的选择性吸附性能［J］. 武汉工程大学学报，2023，45（1）：25-34.
［38］ LUO X G， CAI Y X， LIU L M， et al. Cr(VI) adsorption performance and mechanism of an effective activated carbon prepared from bagasse with a one-step pyrolysis and ZnCl2 activation method ［J］. Cellulose，2019，26（8）：4921-4934.
［39］ YANG C， WANG L R，YU Y Q，et al. Highly efficient removal of amoxicillin from water by Mg-Al layered double hydroxide/cellulose nanocomposite beads synthesized through in-situ coprecipitation method ［J］. International Journal of Biological Macromolecules，2020，149：93-100.
［40］ ADHIKARI C，DAS A，CHAKRABORTY A. Zeolitic imidazole framework （ZIF） nanospheres for easy encapsulation and controlled release of an anticancer drug doxorubicin under different external stimuli：a way toward smart drug delivery system ［J］. Molecular Pharmaceutics，2015，12（9）：3158-3166.
［41］ LI C，LIU X Y，ZHANG Y L，et al. Nanochaperones mediated delivery of insulin ［J］. Nano Letters，2020，20（3）：1755-1765.
［42］ AGGRAWAL S，CHAUHAN I，MOHANTY P. Immobilization of Bi2O3 nanoparticles on the cellulose fibers of paper matrices and investigation of its antibacterial activity against E. coli in visible light ［J］. Materials Express，2015，5（5）：429-436.
［43］ CHAUHAN I， MOHANTY P. Immobilization of titania nanoparticles on the surface of cellulose fibres by a facile single step hydrothermal method and study of their photocatalytic and antibacterial activities ［J］. RSC Advances，2014，4（101）：57885-57890.
［44］ SU Z P，ZHANG M Y，LU Z Q，et al. Functionalization of cellulose fiber by in situ growth of zeolitic imidazolate framework-8 （ZIF-8） nanocrystals for preparing a cellulose-based air filter with gas adsorption ability ［J］. Cellulose，2018，25（3）：1997-2008.

相似文献/References:

备注/Memo

备注/Memo:
收稿日期：2023-03-14
基金项目：国家自然科学基金（51773159）
作者简介：郭远哲，硕士研究生。Email：[email protected]
*通信作者：罗晓刚，博士，教授。Email：[email protected]
引文格式：郭远哲，毛思颖，罗晓刚. 原位制备ZIF-8/纤维素微球及其控制释放5-氟尿嘧啶的研究［J］. 武汉工程大学学报，2024，46（2）：137-147.
更新日期/Last Update: 2024-05-01