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[1]肖艳华,冯睿杰.雷贝拉唑合成研究进展[J].武汉工程大学学报,2012,(1):14-18.
　XIAO Yan hua,FENG Rui jie. Progress on synthesis of rabeprazole[J].Journal of Wuhan Institute of Technology,2012,(1):14-18.
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《武汉工程大学学报》[ISSN:1674-2869/CN:42-1779/TQ]

卷:
期数:
2012年1期
页码:
14-18
栏目:
化学与化学工程
出版日期:
2012-02-28

文章信息/Info

Title:
 Progress on synthesis of rabeprazole
文章编号:
16742869(2012)1001405
作者:
肖艳华; 冯睿杰
武汉工程大学化工与制药学院，绿色化工过程教育部重点实验室，湖北省新型反应器与绿色化学工艺重点实验室，湖北 武汉 430074
Author(s):
XIAO Yanhua;  FENG Ruijie
1 School of Chemical Engineering & Pharmacy, Wuhan Institute of Technology; Key Laboratory
for Green Chemical Process of Ministry of Education, Hubei Key Laboratory of novel reactor &
green Chemical Technology,Wuhan 430074,China
关键词:
雷贝拉唑钠; 合成; 工艺改进
Keywords:
rabeprazole;  synthesis; improvement of technology
分类号:
R975+.2
DOI:
-
文献标志码:
AAdoi:10.3969/j.issn.16742869.2012.1.004
摘要:
介绍了第二代质子泵抑制剂雷贝拉唑合成的关键中间体2\|{［4\|（3\|甲氧基丙氧基）\|3\|甲基吡啶\|2\|基］甲基硫}\|1H\|苯并咪唑，按照化学结构的特点，通过先4\|位氯代法、先2\|位硫醚化法、先2\|位酰化法3种合成路线，以及将其氧化成亚砜的不同氧化方法对这些方法的收率、副产物等方面的优劣进行了比较，并对一条更为简洁的、绿色的合成路线提出了展望
Abstract:
The synthesis of the key intermediate of the second generation proton pump inhibitor rabeprazole by using the first 4\|bit chloride method, the first 2\|bit sulfide method and the first 2\|bit acylation method, 2\|［［(［4\|(3\|methoxypropoxy)\|3\|methyl\|2\|pyridinyl］\|methyl)thio］\|1H\|benzimidazole, and employing various oxidations to perform the sulfide oxidation, were described in detail．The advantages and shortcomings of these methods of yield and by\|products were analyzed and compared together, and the improvement of  concise and green technology was proposed.

参考文献/References:

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