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[1]肖艳华,崔猛,李艳艳.红花的特殊化学成分[J].武汉工程大学学报,2014,(03):36.
　XIAO Yan-hua,CUI Meng,LI Yan-yan.XIAO Yan-hua1, CUI Meng1, LI Yan-yan2[J].Journal of Wuhan Institute of Technology,2014,(03):36.
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红花的特殊化学成分()
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《武汉工程大学学报》[ISSN:1674-2869/CN:42-1779/TQ]

卷:
期数:
2014年03期
页码:
36
栏目:
出版日期:
2014-03-31

文章信息/Info

Title:
XIAO Yan-hua1, CUI Meng1, LI Yan-yan2
作者:
肖艳华1; 崔猛1; 李艳艳2
(武汉工程大学化工与制药学院,湖北 武汉430074)
Author(s):
XIAO Yan-hua1;  CUI Meng1;  LI Yan-yan2
(School of Chemical Engineering & Pharmacy, Wuhan Institute of Technology; Wuhan 430074, China;)
关键词:
红花; 化学成分; 分离纯化; 香豆素
Keywords:
safflower carthamus;  chemical constituents;  separation and purification;  coumarin
分类号:
TQ463+.6
DOI:
-
文献标志码:
-
摘要:
红花资源丰富且有悠久的民间用药历史，为了寻找其活性成分，丰富红花化合物的类型，对红花的化学成分进行系统的研究。用75%乙醇提取红花，所得浸膏以水稀释，再以石油醚、氯仿、乙酸乙酯和正丁醇萃取，对氯仿和乙酸乙酯浸膏部分以各种硅胶柱色谱和重结晶分离纯化，利用溶解性、颜色反应等理化性质以及红外光谱、质谱及氢(1)核磁共振等波谱数据确定了分离所得物质的结构。从红花中分离并鉴定了3个化合物，分别为:3-（3’,4’-二甲氧基苯基）-7-羟基-8-（3-甲基丁基）-香豆素(1), 1-（2-吡啶基）-3-戊酮(2), α-甲氧基苯乙酸-1-十一烷基十二烷酯(3)。这3个化合物均为首次从该植物中分离得到。
Abstract:
Safflower carthamus is rich in resources and has a long medication history. To find the active ingredient and enrich the types of compounds, a systematic research on its chemical constituents was carried out. The chemical constituents of S. carthamus were extracted by 75% ethanol. The residue was suspended in water and then extracted successively with Petroleum ether, chloroform, ethyl acetate and n-butanol. Chloroform part and ethyl acetate part were isolated and purified by silica gel column chromatography and recrystallization. Their structures were characterized by solubility, chromogenic reaction, infrared, mass spectrometry and 1H NMR. Three compounds including Coumarin, 3-(3’,4’- dimethoxyphenyl) -7-hydroxyl -8- (3- methylbut- hyl)(1), 3-Pentone, 1-(2-pyridinyl)(2), Benzeneacetic acid, α-methoxy-1-undecyldodecyl ester(3) were isolated and identified. All of them were obtained from this plant for the first time

参考文献/References:

[1] 杨丽华, 张敏, 马春. 红花的现代研究进展[J].中国老年学杂志,2007, 27 (14): 1429-1430.
Yang Li Hua, Zhang Min, Ma Chun. Research燿evelopment of Safflower carthamus[J]. Chinese Journal of Gerontology, 2007, 27 (14): 1429-1430.
[2]You Li Sha, An Rui, Wang Xin Hong. Discovery of novel osthole derivatives as potential anti-breast cancer treatment[J]. Bioorganic & Medicinal Chemistry Letters, 2010, 20 (24): 7426-7428.
[3]Sukhen C. Ghosh, Edmond Auzenne. N, N-Dimethylsphingosine-Coumarin: Synthesis, Chemical Characterization, and Biological Evaluation[J]. Bioconjugate Chem., 2007, 18 (3): 731-735.
[4]Michael Rychlik. Quantification of Free Coumarin and Its Liberation from Glucosylated Precursors by Stable Isotope Dilution Assays Based on Liquid Chromatography-Tandem Mass Spectrometric Detection[J]. J. Agric. Food Chemical, 2008, 56 (3): 796-801.

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备注/Memo

备注/Memo:
收稿日期：2013-12-16作者简介: 肖艳华 (1971-)，女，湖北武汉人，副教授,博士
更新日期/Last Update: 2014-03-12