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[1]马密霞,秦 宁,闵 清,等.抗新型冠状病毒肺炎药物研究进展[J].武汉工程大学学报,2020,42(03):237-245,252.[doi:10.19843/j.cnki.CN42-1779/TQ. 202004006]
 MA Mixia,QIN Ning,MIN Qing,et al.Research Progress in Anti-COVID-19 Drugs[J].Journal of Wuhan Institute of Technology,2020,42(03):237-245,252.[doi:10.19843/j.cnki.CN42-1779/TQ. 202004006]
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抗新型冠状病毒肺炎药物研究进展(/HTML)
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《武汉工程大学学报》[ISSN:1674-2869/CN:42-1779/TQ]

卷:
42
期数:
2020年03期
页码:
237-245,252
栏目:
化学与化学工程
出版日期:
2023-03-14

文章信息/Info

Title:
Research Progress in Anti-COVID-19 Drugs
文章编号:
1674 - 2869(2020)03 - 0237 - 09
作者:
马密霞13秦 宁24闵 清2胡文祥*1245
1. 武汉工程大学化学与环境工程学院,湖北 武汉 430205;2. 湖北科技学院药学院,湖北 咸宁 437100;3. 北京联合大学智慧城市学院,北京 100101;4. 北京神剑天军医学科学院京东祥鹄微波化学联合实验室,北京 101601;5. 中国人民解放军战略支援部队航天系统部,北京 100101
Author(s):
MA Mixia 13 QIN Ning 24 MIN Qing 2 HU Wenxiang*1245
1.School of Chemistry and Environmental Engineering, Wuhan Institute of Technology, Wuhan 430205 , China; 2.School of Pharmacy, Hubei University of Science and Technology, Xianning 437100, China;3.Smart City College, Beijing Union University, Beijing 100101,China; 4.Jingdong Xianghu Microwave Chemistry Union Laboratory, Beijing Shenjian Tianjun Academy of Medical Sciences, Beijing 101601, China;5.Space Systems Division,Strategic Support Troops,Chinese People’s Liberation Army,Beijing
关键词:
新型冠状病毒COVID-19抗病毒药物中药疫苗老药新用组合疗法药效团
Keywords:
novel corona virus COVID-19 antiviral drugs Chinese traditional medicine vaccineconventional drug in new use combination therapy pharmacophore
分类号:
R373.1
DOI:
10.19843/j.cnki.CN42-1779/TQ. 202004006
文献标志码:
A
摘要:
抗新型冠状病毒肺炎药物是阻止病毒传播、遏制疫情的有效手段,收集整理了各国科研机构关于治疗COVID-19的药物及相关研究信息,主要包括可能用于治疗COVID-19的化学药、中药和生物药物等的研究情况;综述了瑞德西韦、法维拉韦、氯喹和羟氯喹等化学药及其联合用药的临床试验初步研究,介绍了“金花清感颗粒”、“连花清瘟胶囊/颗粒”、“血必净注射液”、“清肺排毒汤”、“化湿败毒方”、“宣肺败毒方”等中药及其功效,以及生物大分子药物如治愈患者血浆抗体、托珠单抗、干扰素和疫苗研发等情况。今后,仍需不断完善各种药物治疗COVID-19的临床试验,加快疫苗研发等,进一步探讨防治COVID-19的策略,旨在为治疗新型冠状病毒肺炎的药物筛选提供参考。
Abstract:
Antiviral drugs are effective treatments of COVID-19 to control the epidemic by preventing virus spreading. This review summarizes the current status of research and development of COVID-19 treatments around the world, including chemical medicine, traditional Chinese medicine and biological medicine, etc. The review compiles preliminary studies and clinical trial results of chemical drugs such as Remdesivir, Favipiravjr, Chloroquine, Hydroxychloroquine and combined medication. The present review also introduces traditional Chinese medicines such as "Jinhua Qinggan Granule", "Lianhua Qingwen Capsules/Granule", "Xuebijing Injection", "Lungs Detox Soup", "Hua Shi Bai Du Fang" and "Xuan Fei Bai Du Fang" as well as their effects. In addition, current development of biomacromolecule drugs such as cured patient plasma, Tocilizumab, interferon and vaccines are presented in this paper. In the future, it is still necessary to improve the clinical trials of various drugs for COVID-19 and speed up vaccine development, etc.. Finally, this review investigates the future strategies to prevent and treat COVID-19, hopefully providing reference for the drug screening of COVID-19.

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备注/Memo:
收稿日期:2020-04-10作者简介:马密霞,博士研究生,副教授。E-mail:[email protected]*通讯作者:胡文祥,博士,教授,博士研究生导师。E-mail:[email protected]引文格式:马密霞,秦宁,闵清,等. 抗新型冠状病毒肺炎药物研究进展[J]. 武汉工程大学学报,2020,42(3):237-245,252.
更新日期/Last Update: 2020-07-09