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[1]王映桂,张思洁,刘　璨,等.可降解自愈合壳聚糖/瓜尔胶水凝胶的制备与性能[J].武汉工程大学学报,2020,42(03):302-306.[doi:10.19843/j.cnki.CN42-1779/TQ.202002001]
　WANG Yinggui,ZHANG Sijie,LIU Can,et al.Preparation and Properties of Degradable and Self-Healing Chitosan/Guar Gum Hydrogels[J].Journal of Wuhan Institute of Technology,2020,42(03):302-306.[doi:10.19843/j.cnki.CN42-1779/TQ.202002001]
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可降解自愈合壳聚糖/瓜尔胶水凝胶的制备与性能(/HTML)
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《武汉工程大学学报》[ISSN:1674-2869/CN:42-1779/TQ]

卷:
42
期数:
2020年03期
页码:
302-306
栏目:
材料科学与工程
出版日期:
2023-03-14

文章信息/Info

Title:
Preparation and Properties of Degradable and Self-Healing Chitosan/Guar Gum Hydrogels
文章编号:
1674 - 2869（2020）03 - 0302 - 05
作者:
王映桂; 张思洁; 刘　璨; 曾小平; 王大威; 吴江渝*
武汉工程大学材料科学与工程学院，湖北 武汉 430205
Author(s):
WANG Yinggui; ZHANG Sijie; LIU Can; ZENG Xiaoping; WANG Dawei; WU Jiangyu*
School of Materials Science and Engineering，Wuhan Institute of Technology，Wuhan 430205， China
关键词:
瓜尔胶; 壳聚糖; 可降解; 自愈合; 水凝胶
Keywords:
guar gum;  chitosan;  degradable;  self-healing;  hydrogel
分类号:
O636.1
DOI:
10.19843/j.cnki.CN42-1779/TQ.202002001
文献标志码:
A
摘要:
可降解自愈合水凝胶在生物医用领域有广泛的应用前景，然而其设计仍面临很大的挑战。用高碘酸钠氧化瓜尔胶（GG）得到醛基化瓜尔胶（AGG）。将AGG与壳聚糖（CS）混合，AGG链上的醛基与CS链上的氨基进行席夫碱（Schiff base）反应形成动态亚胺键，从而得到壳聚糖/醛基化瓜尔胶（CS/AGG）水凝胶。该水凝胶拥有较好的自愈合性和可降解性。利用核磁共振氢谱（1H-NMR）对AGG进行了结构表征，结果表明GG成功被氧化成AGG。利用动态流变性能测试对水凝胶进行模量表征，频率扫描结果表明当CS和AGG的体积比在1∶5时水凝胶储能模量最高为400 Pa；动态交替时间扫描结果表明该水凝胶能在5 min内实现快速自愈合。降解性能测试表明CS/AGG水凝胶在pH=6.8和pH=7.4的环境下7 d内降解率可达65%。所制备的CS/AGG水凝胶的自愈合性和可降解性为其在可降解医用伤口敷料和药物释放等方面的应用提供能了可能性。
Abstract:
Degradable and self-healing hydrogels are widely used in biomedical field，while the design of hydrogel structure is still a challenge. Herein we developed chitosan/aldehyde guar gum （CS/AGG） hydrogels by mixing CS and AGG which resulted from the oxidization of guar gum （GG） by sodium periodate. Schiff base reaction occurred between aldehyde groups of AGG and amino groups of CS to form dynamic imine linkages. The CS/AGG hydrogels present good self-healing and degradable properties. 1H-nuclear magnetic resonance spectroscopy （1H-NMR） was utilized to characterize the chemical structure of AGG，and the result indicates that the GG is successfully oxidized to AGG. The dynamic rheological tests were used to measure the modulus of hydrogels. The result of frequency scan shows that the highest modulus of hydrogels is around 400 Pa when the volume ratio of CS and AGG is 1∶5. In addition，the results of dynamic alternate time scan show that the self-healing process of CS/AGG hydrogels can finish in 5 min. Degradation tests demonstrate that the hydrogel reaches a high degradation of 65% at pH 6.8 and 7.4 in 7 days. These results indicate that CS/AGG hydrogels can be applied in degradable wound dressings and drug delivery due to their self-healing and degradable properties.

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备注/Memo

备注/Memo:
收稿日期：2020-02-01基金项目：武汉工程大学第九届研究生教育创新基金（CX2017007）作者简介：王映桂，硕士研究生。E-mail： [email protected]*通讯作者：吴江渝，博士，教授。E-mail： [email protected]引文格式：王映桂，张思洁，刘璨，等. 可降解自愈合壳聚糖/瓜尔胶水凝胶的制备与性能［J］. 武汉工程大学学报，2020，42（3）：302-306.
更新日期/Last Update: 2020-07-09